منابع مشابه
The restricted expression of granzyme M in human lymphocytes.
We have analyzed the expression of human granzyme M (Gzm M) in various human leukocyte subsets using the specific mAb 4H10. Using FACS and Western blotting analysis we compared the expression of Gzm M with that of other granzymes (Gzm A and Gzm B) and the lytic protein perforin. Human Gzm M was constitutively highly expressed in NK cells as was perforin and Gzm A. Surprisingly, freshly isolated...
متن کاملGranzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B.
Granzyme M is a trypsin-fold serine protease that is specifically found in the granules of natural killer cells. This enzyme has been implicated recently in the induction of target cell death by cytotoxic lymphocytes, but unlike granzymes A and B, the molecular mechanism of action of granzyme M is unknown. We have characterized the extended substrate specificity of human granzyme M by using pur...
متن کاملFunctional analysis of granzyme M and its role in immunity to infection.
Cytotoxic lymphocytes express a large family of granule serine proteases, including one member, granzyme (Grz)M, with a unique protease activity, restricted expression, and distinct gene locus. Although a number of Grzs, including GrzM, have been shown to mediate target cell apoptosis in the presence of perforin, the biological activity of Grz has been restricted to control of a number of viral...
متن کاملA role for granzyme M in TLR4-driven inflammation and endotoxicosis.
Lymphocyte perforin and serine protease granzymes are well-recognized extrinsic mediators of apoptosis. We now demonstrate that cytotoxic lymphocyte granule components profoundly augment the myeloid cell inflammatory cytokine cascade in response to TLR4 ligation. Whereas caspase-1-deficient mice were completely resistant to LPS, reduced serum cytokine production and resistance to lethal endotox...
متن کاملKnow Your Enemy: Honeynets
Over the past several years the Honeynet Project has been dedicated to learning the tools, tactics, and motives of the blackhat community and sharing the lessons learned. The primary tool used to gather this information is the Honeynet. The purpose of this paper is to discuss what a Honeynet is, its value, how it works, and the risks/issues involved. It is hoped that the security community can ...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2014
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2013.189